Table 3.
Distribution of analyzed protein targets from autism subjects relative to controls
| Autism patients with no seizure disorder | Autism patients with seizure disorder | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AN01093 (A1) | AN00764 (A3) | AN00493 (A6) | UMB1182 (A9) | AN06420 (A5) | UMB797 (A8) | AN08873 (A7) | UMB1174 (A2) | AN08792 (A4) | AN16641 (A10) | AN16615 (A11) | |
| TrkB-FL | −2.0 SD | −1.5 SD | −2.0 SD | −1.5 SD | 0.5 SD | −0.5 SD | 0.5 SD | −2.0 SD | −2.0 SD | −1.5 SD | −1.5 SD |
| PI3K p85 | −2.0 SD | −1.5 SD | −2.0 SD | −2.0 SD | 0.5 SD | −0.5 SD | 0.5 SD | −2.0 SD | −2.0 SD | 1.5 SD | −1.5 SD |
| Akt | −2.0 SD | −0.5 SD | −1.5 SD | −2.0 SD | 1.5 SD | −0.5 SD | 0.5 SD | −1.5 SD | −1.5 SD | −0.5 SD | −1.5 SD |
| mTOR | −2.0 SD | −2.0 SD | −2.0 SD | −2.0 SD | 1.5 SD | −0.5 SD | 0.5 SD | −2.0 SD | −2.0 SD | −1.5 SD | −2.0 SD |
| Phospho-mTOR | −1.5 SD | −2.0 SD | −2.0 SD | −2.0 SD | 0.5 SD | −0.5 SD | −0.5 SD | −2.0 SD | −2.0 SD | −2.0 SD | −2.0 SD |
|
p70 S6
Kinase |
−2.0 SD | −1.5 SD | −1.5 SD | −2.0 SD | 0.5 SD | −0.5 SD | −0.5 SD | −1.5 SD | −2.0 SD | −1.5 SD | −1.5 SD |
| eIF4B | −2.0 SD | −2.0 SD | −2.0 SD | −1.5 SD | 1.5 SD | 2.0 SD | −0.5 SD | −1.5 SD | −2.0 SD | −2.0 SD | −2.0 SD |
| PSD-95 | −1.5 SD | −1.5 SD | −1.5 SD | −1.5 SD | 0.5 SD | 0.5 SD | 0.5 SD | −1.5 SD | −1.5 SD | −1.5 SD | −1.5 SD |
SD = Standard deviation. The mean of each target for the control group was used as a reference to calculate the corresponding standard deviation values for each target. Bold-Italics = 0.5-2.0 standard deviations less than the mean of controls. Not Bold = 0.5-2.0 standard deviations greater than the mean of controls.