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. Author manuscript; available in PMC: 2015 Jan 27.
Published in final edited form as: J Control Release. 2013 Oct 8;172(3):690–698. doi: 10.1016/j.jconrel.2013.09.027

Fig. 4. Mechanisms of siRNA delivery by DOTMA-OA LNPs.

Fig. 4

(A) A cryo-TEM image of nanostrucure of siRNA-DOTMA based LNPs containing OA. White arrows show the onion-like structure of LNPs. (B) Stability of DOTMA based LNPs containing EggPC, OA, LA and LNA. (C) Measurement of pH-dependent zeta potential of DOTMA based LNPs. (D) Co-localization study of DOTMA-OA-Cy3-siRNA (red) with lysotracker (green). Red arrows indicate the co-localization. Scale bar=20 μm.