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. Author manuscript; available in PMC: 2015 Jan 27.
Published in final edited form as: Endocr J. 2009 Jul 17;56(6):729–737. doi: 10.1507/endocrj.k09e-185

Figure 1. Model for regulation of signaling by the GnRH-R in response to tonic or pulsatile GnRH.

Figure 1

Tonic GnRH stimulation (left) causes a transient increase in Gs/cAMP signaling that rapidly returns to baseline in spite of the continued presence of GnRH. In contrast, Gq/11/DAG/Ca2+ signaling remains elevated during the entire period of GnRH stimulation. Pulsatile GnRH (right) causes matching pulses of Gs/cAMP signaling of constant amplitude over time. Gq/11/DAG/Ca2+ signaling shows an initial pulse matching the GnRH pulse but each subsequent pulse has lower amplitude until no further pulses are seen after 2 h. This may reflect a PKC or CaMK induced negative feedback loop to desensitize Gq/11 signaling.