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. Author manuscript; available in PMC: 2015 Jan 27.
Published in final edited form as: Expert Opin Drug Discov. 2014 Jan 22;9(3):299–318. doi: 10.1517/17460441.2014.877884

Figure 1.

Figure 1

A schematic model of Bacillus anthracis toxins cell entry. The numbers 1-8 indicate the eight main points at which antitoxins reviewed in the current article can act. Specifically, the potential agents can target PA-receptor binding (step 1), inhibit extracellular furin (step 2), prevent oligomeric PA63 prepore assembly (step 3), obstruct LF and EF binding (step 4), prevent endocytosis (step 5), impede oligomeric PA63 prepore-to-pore conversion (step 6), inhibit LF and EF PA-mediated translocation from endosomes (step 7), obstruct LF and EF enzymatic activity (step 8).