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. Author manuscript; available in PMC: 2015 Jan 27.
Published in final edited form as: Expert Opin Drug Discov. 2014 Jan 22;9(3):299–318. doi: 10.1517/17460441.2014.877884

Figure 5.

Figure 5

Small molecule inhibitors of LF and EF. (A) Structure of PT-8420 and PT-8541 - small molecule compounds that were identified and characterized for their ability to protect animals from death in a rat model of LT intoxication with IC50 values of 0.33 and 0.04 nM, respectively (141). (B) Small-molecule EF inhibitors. Left: Structure of compound 22, one of the (M)ANT nucleotides inhibiting with IC50= 10 nM (157). Right: Structure for an optimized EF inhibitor, compound 22 (159) inhibiting EF-induced secretion of cAMP by cultured cells with IC50 = 2.71 μM.