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. 2015 Jan 9;22:4. doi: 10.1186/s12929-014-0108-9

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© Subramanian et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Schematic showing the cell specific silencing strategy mediated by PEI nanocomplex fabricated with aptamer and siRNA. PEI nanoparticle is formed using sodium citrate as charge stabilizer, followed by the addition of siRNA and EpCAM aptamer to form the PEI-Apt-siRNA complex. This complex guided by the aptamer, binds to the EpCAM positive cells and delivers the siRNA in the cytoplasm resulting in target gene silencing and inhibition of cellular function pertained to it.