Table 4.
Stage of Lung Cancers, According to Screening Round, Study Group, and Screening Result.*
| Screening Round and Stage |
Low-Dose CT | Chest Radiography | ||||||
|---|---|---|---|---|---|---|---|---|
| Positive | Negative | No Screening |
Total | Positive | Negative | No Screening |
Total | |
| number/total number (percent) | ||||||||
| T1 screening round | ||||||||
| Stage IA | 86/165 (52.1) | 1/10 (10.0) | 0 | 87/183 (47.5) | 23/65 (35.4) | 6/43 (14.0) | 2/24 (8.3) | 31/132 (23.5) |
| Stage IB | 18/165 (10.9) | 1/10 (10.0) | 2/8 (25.0) | 21/183 (11.5) | 9/65 (13.8) | 1/43 (2.3) | 1/24 (4.2) | 11/132 (8.3) |
| Stage IIA | 11/165 (6.7) | 0 | 0 | 11/183 (6.0) | 4/65 (6.2) | 2/43 (4.7) | 1/24 (4.2) | 7/132 (5.3) |
| Stage IIB | 6/165 (3.6) | 0 | 1/8 (12.5) | 7/183 (3.8) | 3/65 (4.6) | 1/43 (2.3) | 1/24 (4.2) | 5/132 (3.8) |
| Stage IIIA | 13/165 (7.9) | 1/10 (10.0) | 0 | 14/183 (7.7) | 6/65 (9.2) | 6/43 (14.0) | 2/24 (8.3) | 14/132 (10.6) |
| Stage IIIB | 13/165 (7.9) | 4/10 (40.0) | 2/8 (25.0) | 19/183 (10.4) | 2/65 (3.1) | 6/43 (14.0) | 4/24 (16.7) | 12/132 (9.2) |
| Stage IV | 18/165 (10.9) | 3/10 (30.0) | 3/8 (37.5) | 24/183 (13.1) | 18/65 (27.7) | 21/43 (48.8) | 13/24 (54.2) | 52/132 (39.4) |
| Unknown† | 3/168 (1.8) | 0 | 0 | 3/186 (1.6) | 0 | 1/44 (2.3) | 0 | 1/133 (0.8) |
| T2 screening round | ||||||||
| Stage IA | 113/204 (55.4) | 2/16 (12.5) | 1/10 (10.0) | 116/230 (50.4) | 27/77 (35.1) | 4/44 (9.1) | 4/22 (18.2) | 35/143 (24.5) |
| Stage IB | 28/204 (13.7) | 0 | 3/10 (30.0) | 31/230 (13.5) | 10/77 (13.0) | 3/44 (6.8) | 0 | 13/143 (9.1) |
| Stage IIA | 8/204 (3.9) | 0 | 0 | 8/230 (3.5) | 7/77 (9.1) | 0 | 2/22 (9.1) | 9/143 (6.3) |
| Stage IIB | 3/204 (1.5) | 2/16 (12.5) | 0 | 5/230 (2.2) | 0 | 3/44 (6.8) | 0 | 3/143 (2.1) |
| Stage IIIA | 15/204 (7.4) | 0 | 0 | 15/230 (6.5) | 10/77 (13.0) | 7/44 (15.9) | 1/22 (4.5) | 18/143 (12.6) |
| Stage IIIB | 15/204 (7.4) | 4/16 (25.0) | 1/10 (10.0) | 20/230 (8.7) | 10/77 (13.0) | 6/44 (13.6) | 5/22 (22.7) | 21/143 (14.7) |
| Stage IV | 22/204 (10.8) | 8/16 (50.0) | 5/10 (50.0) | 35/230 (15.2) | 13/77 (16.9) | 21/44 (47.7) | 10/22 (45.5) | 44/143 (30.8) |
| Unknown‡ | 7/211 (3.3) | 0 | 0 | 7/237 (3.0) | 1/78 (1.3) | 0 | 0 | 1/144 (0.7) |
*
Cancer-stage classification was based on the sixth edition of the Cancer Staging Manual of the American Joint Committee on Cancer.7 The denominators for cancer stage were the total number of lung cancers of known stage in each screening-result category.
†
The lung cancers of unknown stage at the T1 screening round included 4 cancers with stage information that could not be classified.
‡
The lung cancers of unknown stage at the T2 screening round included 2 carcinoids, 1 occult carcinoma, 1 with no evidence of malignancy, and 4 with stage information that could not be classified.