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. Author manuscript; available in PMC: 2015 Jan 27.
Published in final edited form as: Cancer Res. 2009 Jan 27;69(3):1000–1008. doi: 10.1158/0008-5472.CAN-08-2367

Figure 4.

Figure 4

Curcumin inhibits mTORC1 signaling independently of TSC. A, Rh1 cells were exposed to curcumin (0–40 μmol/L) for 2 h, followed by stimulation with IGF-I (10 ng/mL) for 1 h. TSC2 was immunoprecipitated (IP) from the cell lysates, followed by immunoblotting with the indicated antibodies. B, MEF/TSC2−/− and wt cells were exposed to curcumin (0–50 μmol/L) for 2 h, followed by stimulation with IGF-I (10 ng/mL) for 1 h. Cell lysates were subjected to Western blot analysis using the indicated antibodies.