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. 2015 Jan 23;12:13. doi: 10.1186/s12974-014-0231-2

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© Worthmann et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A-D Temporal profile of LBP, IL-10, IL-6 and CRP in patients with and without infection. Comparison of time courses between patients with (n = 16) and patients without (n = 16) infection matched for S100B peak levels for the extent of brain damage. Data are presented as median with interquartile range. Intergroup comparisons between patients with and without infection: *P ≤0.05; **P ≤0.01; ***P ≤0.001. Within-group comparisons of marker levels between initial (6 h) and follow-up time points: Patients with infection: significant differences were detected for LBP (6 h versus 12 h: P = 0.001, 6 h versus 24 h: P = 0.001, 6 h versus 3 d: P = 0.01) and CRP (6 h versus 12 h: P = 0.002, 6 h versus 24 h: P = 0.001, 6 h versus 3 d: P = 0.002). Patients without infection: significant differences were detected for LBP (6 h versus 24 h: P = 0.005, 6 h versus 3 d: P = 0.005, 6 h versus 7 d: P = 0.007) and CRP (6 h versus 24 h: P = 0.001).