Table 2.

Comparison of severe deterioration at least five years after first admission of schizophrenic patients to Norway’s Gaustad hospital from 1938 to 1950 (pre-antipsychotic medication era) and from 1951 to 1957 (antipsychotic medication era). Only patients receiving antipsychotic medications were included in the 1951 to 1957 group

Treatment	n	% (n) patients with severe deterioration
Preneuroleptic	1102	16 (176)
Neuroleptic	237	9 (21)
Two-sample proportional test	p=0.003

Data adapted from Astrup & Noreik (1966) and Wyatt (1991).