A. Mean IOP ± SEM. Animals that were to be maintained for 48 weeks were re-injected (dotted line) after 24 weeks. Mean IOP for bead-injected eyes (“Beads,” green), contralateral uninjected eyes (“Contralateral,” blue), and their difference (“Difference,” red) is presented. Bead injection results in a statistically significant IOP elevation (ANOVA with repeated measures, p < 0.001). B. Mean Cumulative IOP difference ± SEM. Bead-injected eyes (green) are subject to a statistically larger cumulative IOP than are saline-injected eyes (blue; ANOVA with repeated measures, p < 0.001).