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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Exp Eye Res. 2014 Nov 18;130:29–37. doi: 10.1016/j.exer.2014.11.007

Figure 2. Prolonged IOP elevation results in RGC loss.

Figure 2

Examples of uninjected eyes (“No Beads”; panels A, C, E) and bead-injected eyes (“Beads”; panels B, D, F) are presented side by side at 24 weeks after injection (panels A and B), or 48 weeks after injection (panels C–F). A–D. Retinal flat mounts. E, F. Retinal cross sections. A, B. Neurobiotin-staining. C, D. TUJ1-staining. E, F. TO-PRO3 staining. An extreme example of RGC loss (F) is shown in comparison with a typical control retina (E). The INL and ONL are of equivalent thickness. ONL = outer nuclear layer; INL = inner nuclear layer; GCL = ganglion cell layer.