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. 2015 Jan 27;10(1):e0116868. doi: 10.1371/journal.pone.0116868

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© 2015 Paiva et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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MiR-155 levels are significantly higher in normal chest skin compared with ear skin samples. Targeted expression of HPV-16 oncogenes to basal keratinocytes leads to multistep skin carcinogenesis–transgenic ear skin samples showed CIS while chest samples showed epidermal hyperplasia. Hyperplastic (chest) skin samples showed a significant miR-155 downregulation compared with matched wild-type samples. No differences were observed between wild-type and transgenic ear samples or between transgenic ear and chest samples.