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. 2015 Jan 27;10(1):e0114050. doi: 10.1371/journal.pone.0114050

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© 2015 Yates et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The disease in question was dementia associated with AD. The graph shows the disease free survival probability of subjects prior to the age of 75, in subgroups defined by the p21^cip1 genotype. Prior to the age of 75, the variant p21^cip1 was associated with a significant reduction in the disease free survival compared to the common p21^cip1 (hazard ratio: 1.698, p-value: 0.017). The x-axis represents the age in years. The y-axis represents the survival probability expressed as a percentage. The solid black line represents subjects that were homozygous for the common p21^cip1. The broken grey line represents subjects that were heterozygous or homozygous for the variant p21^cip1.