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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Acta Physiol (Oxf). 2015 Jan 5;213(3):586–594. doi: 10.1111/apha.12442

Figure 1.

Figure 1

Effects of CGRP in vitro. Pre-exposure of murine LC to CGRP inhibits antigen presentation for Th1 cell generation while enhancing antigen presentation for Th2 cell generation. The simultaneous presence of CGRP inhibits interferon-γ-induced production of the Th1 chemokines CXCL9 and CXCL10 by a LC-like cell line derived form BALB/c epidermis while treatment with CGRP alone induced production of the Th2 chemokines CCL17 and CCL22 (Ding et al. 2008). Additionally, CGRP inhibits lipopolysaccharide (LPS)-induced production of CXCL1, CXCL8 and CCL2 by human dermal microvascular endothelial cells (cells were cultured in CGRP and 1 hour later LPS was added without removing the CGRP) (Huang et al. 2011).