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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Curr Opin Chem Biol. 2014 Nov 15;0:27–37. doi: 10.1016/j.cbpa.2014.10.020

Figure 4. Chemical methods to enrich lipidated proteins.

Figure 4

(A, B) Treatment of cells with alkyne myristic acid (Alk-12) or alkyne palmitic acid (Alk-16) results in labeling of N-myristoylated proteins or S-palmitoylated proteins, respectively. (C) Acyl-biotin exchange: S-palmitoylated proteins can be tagged post-lysis by using a combination of thiol- and thioester-selective reactions. (D) Treatment of cells with alkyne farnesol results in labeling of S-prenylated proteins.