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Heat-triggered drug release. Specially-designed Thermodox liposomes extravasate into the tumor through pores in leaky tumor blood vessels (A). Hyperthermia increases the blood vessel pore sizes (B). Hyperthermia triggers drug release from the liposomes in both the tumor blood vessels (C) and the tumor tissue (D). Hyperthermia itself can also be toxic to cancer cells (E). Reprinted with permission from reference 78. Copyright 2000, American Association for Cancer Research.
