Table 2. DTI study of healthy relatives of SZ and related disorders and bipolar disorders.

Authors	Sample	Mean age (years) ±SD	DTI method	Analysis method	Abnormalities in relatives compared to healthy controls	Additional modalities	Comments/limitations
Skudlarski et al., 2013	119 Relatives (SZ+SZAF depression) 83 Relatives (pBD+SZAF manic) 104 HC 125 SZ+SZAF (depression) 82 pBD+SZAF (manic)	42.5±1.5 40.6±2.5 38.9±1.3 33.8±1.0 36.4±1.4	3 T	TBSS ROI	Relatives of SZ+SZAF depression had significantly decreased FA in: Genu of CC Left ACR Right ACR Right PCR Left PCR superior aspect Right ACR superior aspect Left ACR superior aspect Right ACR inferior aspect Left ACR inferior aspect Right ACR middle frontalgyrus WM Relatives pBD+SZAF (manic) had significantly decreased FA in right PCR superior aspect	Cluster A or B traits in relatives Heritability Correlation with Schizo-Bipolar Scale Demographic measures Medication	Relatives and HC were free of current Axis I disorders Relatives were classified by the presence or absence of symptoms of DSM-IV-TR cluster A and cluster B personality disorders

HC, healthy controls; SZ, schizophrenia; SZAF, schizoaffective disorder; pBD, psychotic bipolar disorder; DTI, diffusion tensor imaging; ROI, region of interest; TBSS, tract-based spatial statistics; FA, fractional anisotropy; WM, white matter; CC, corpus callosum; ACR, anterior corona radiata; PCR, posterior corona radiata; DSM-IV-TR; Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision