Table 3. Biochemical results.

Parameter	Control (n = 18)	HTDD− (n = 38)	HTDD+ (n = 56)
PC, µmol/g	0.191 ± 0.131	0.306 ± 0.214*	0.29 ± 0.246*
Plasma BH4, nmol/mL	0.917 ± 0.351	1.98 ± 2.1**	2.04 ± 1.99**
Total biopterin, nmol/mL	2.01 ± 0.86	3.05 ± 2.8	2.98 ± 2.46*
CRP, mg/L	1.97 ± 1.67	2.91 ± 2.63	4.17 ± 4.21**
IL-6, pg/mL	1.88 ± 1.04	2.4 ± 2.91	3.0 ± 4.49
TNF-α, pg/mL	0.854 ± 0.778	1.75 ± 2.19*	2.26 ± 4.62*
FIB, g/L	4.03 ± 0.61	4.46 ± 0.93	4.56 ± 0.95
PAI-I, ng/mL	11.62 ± 5.44	21.11 ± 11.21**	21.23 ± 16.16**
VWF, Ag%	168.03 ± 57.59	148.27 ± 39.15	156.58 ± 48.93
cGA, ng/mL	75.85 ± 17.3	136.04 ± 162.71	148.16 ± 166.34**
BNP, pg/mL	15.89 ± 9.24	29.8 ± 32.3*	43.49 ± 69.41**

*P < 0.05, **P < 0.01 vs. the control group. BH₄: tetrahydrobiopterin; BNP: B-type natriuretic peptide; cGA: chromogranin A; CRP: C-reactive protein; FIB: fibrinogen; IL-6: interleukin-6; PAI-I: plasminogen activator inhibitor type I; PC: protein carbonylation; TNF-α: tumor necrosis factor-α; VWF: von Willebrand factor.