Table 2.
Hemodynamic measure | Hazard Ratio Including Standard Risk Factors (LCL, UCL) | P | Hazard Ratio Including Standard Risk Factors and Physician SBP (LCL, UCL) | P | Hazard Ratio Including Standard Risk Factors, Physician SBP, and CFPWV (LCL, UCL) | P |
---|---|---|---|---|---|---|
Physician SBP | 1.26 (1.07, 1.48) | 0.005 | - | - | - | - |
Tonometry mean arterial pressure | 1.10 (0.94, 1.29) | 0.25 | 0.92 (0.75, 1.13) | 0.45 | 0.98 (0.79, 1.22) | 0.88 |
Forward pressure wave amplitude | 1.40 (1.16, 1.67) | <0.001 | 1.32 (1.06, 1.64) | 0.01 | 1.33 (1.05, 1.68) | 0.02 |
Backward pressure wave amplitude | 1.30 (1.10, 1.53) | 0.002 | 1.20 (0.98, 1.47) | 0.08 | 1.21 (0.97, 1.50) | 0.09 |
Primary pressure wave amplitude | 1.28 (1.07, 1.52) | 0.007 | 1.17 (0.95, 1.44) | 0.13 | 1.16 (0.94, 1.45) | 0.17 |
Global reflection coefficient | 0.95 (0.79, 1.14) | 0.58 | 0.93 (0.78, 1.12) | 0.45 | 0.94 (0.78, 1.13) | 0.52 |
Models add hemodynamic variables to the covariates individually, one at a time. In the center, all models also include physician SBP, and on the right, all models are additionally adjusted for carotid femoral pulse wave velocity (CFPWV). LCL, UCL, lower and upper limits of the 95% confidence intervals; SBP, systolic blood pressure. HRs expressed per 1 SD higher value, adjusted for standard risk factors; 149 events (6%) with median of 5.4 years of follow up.