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Pretreated animals with Frizzled 4 siRNA reversed the effects of Norrin treatment after SAH. The Modified Garcia test (A) results (n=6), (B) Brain water content (n=6) and (C) Evans blue extravasation results (n=5) (D) Representive Evans blue fluorenscence in ipsilateral/left cortex after using pretreated Frizzled 4 siRNA in Norrin treatment groups after SAH. Scr = Scrambled; Fzd4 = Frizzled 4. #: vs. Sham P<0.05 *: vs. SAH+Vehicle P<0.05 &: vs. SAH+Scr siRNA P<0.05.
