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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Curr Opin Chem Biol. 2014 Nov 7;0:1–10. doi: 10.1016/j.cbpa.2014.09.040

Figure 1. Schematic representation of directed evolution.

Figure 1

All complete directed evolution methods must provide four major components: translation, selection or screening, replication, and mutation. Historical examples of each of these components are listed. Techniques that are particularly amenable to in vivo continuous evolution are shown in green.