Table 3. Test characteristics of echocardiography at 2 weeks of life.
| Outcome | Sensitivity | Specificity | Positive Predictive Value | Negative Predictive Value | AUROC (95%CI) |
|---|---|---|---|---|---|
| Death | |||||
|
| |||||
| Any PH | 100% | 48% | 31% | 100% | 0.81 (0.76, 0.86) |
| Severe PH | 74% | 68% | 36% | 92% | 0.73 (0.60, 0.86) |
| Echocardiography Overall§ | - | - | - | - | 0.87 (0.80, 0.94) |
|
| |||||
| Death or Prolonged Intubation (≥28 d) | |||||
|
| |||||
| Any PH | 97% | 51% | 43% | 98% | 0.81 (0.74, 0.88) |
| Severe PH | 58% | 67% | 40% | 81% | 0.64 (0.53, 0.75) |
| Echocardiography Overall | - | - | - | - | 0.83 (0.75, 0.91) |
|
| |||||
| Prolonged Respiratory Support (≥56 d) or Home Oxygen | |||||
|
| |||||
| Any PH | 84% | 54% | 58% | 82% | 0.79 (0.72, 0.88) |
| Severe PH | 47% | 63% | 49% | 61% | 0.61 (0.54, 0.69) |
| Echocardiography Overall | - | - | - | - | 0.80 (0.72, 0.88) |
“Any PH” defined as estimated pulmonary arterial pressures ≥2/3 systemic blood pressures
“Severe PH” defined as estimated pulmonary pressures systemic-to-suprasystemic blood pressures
“Echocardiography overall” defined as three-level classification of estimated pulmonary arterial pressure: < 2/3 systemic blood pressure, ≥ 2/3 systemic blood pressure, systemic-to-suprasystemic blood pressure
Abbreviations: AUROC - area under the reveiver operating curve; CI - confidence interval; PH - pulmonary hypertension