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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Acta Biomater. 2014 Nov 25;14:84–95. doi: 10.1016/j.actbio.2014.11.035

Figure 5. Cell measurements in ECM-Fibrin gels.

Figure 5

(A) Cell viability was significantly lower in 14 kPa (12 μg/ml TG) and 32 kPa (120 μg/ml TG) neonatal ECM-fibrin gels compared to 2 kPa (0 TG) fibrin and ECM-fibrin gels. Cell viability was not significantly affected in adult ECM-fibrin gels crosslinked with TG. (B) Cells were significantly more dense in 2 kPa fibrin control gels compared to all other conditions at 24 hr. (C) Cell numbers increased modestly but significantly in 2 kPa and 8 kPa adult ECM gels compared to 2 kPa fibrin and 14 kPa adult ECM gels. Cell numbers did not change significantly in neonatal ECM-based gels. (D) Network scoring shows a decrease in network formation with increasing Young’s modulus regardless of ECM age. # = significant difference vs. all other conditions; $ = significant difference vs. 2 kPa fibrin and 8 kPa ECM-fibrin for p < 0.05 (N = 3-5 per condition).