Table 4.
Weight Change and Risk of Ulcerative Colitis and Crohn’s Disease (1989–2009)*
| Weight change (lbs) | ||||||
|---|---|---|---|---|---|---|
| < −5 | ≥ −5 and < 5 | ≥ 5 and < 15 | ≥ 15 and < 30 | ≥ 30 | Ptrend | |
| Person-years of follow-up | 200,825 | 311,881 | 559,090 | 500,798 | 449,068 | |
| Crohn’s Disease | ||||||
| No. of cases | 13 | 19 | 37 | 41 | 43 | |
| Age-adjusted HR (95% CI) | 1.07 (0.53–2.16) | 1.00 | 1.10 (0.63–1.91) | 1.39 (0.80–2.40) | 1.68 (0.97–2.90) | 0.03 |
| Multivariate-adjusted HR (95% CI)§ | 0.96 (0.46–2.00) | 1.00 | 1.08 (0.62–1.88) | 1.31 (0.76–2.27) | 1.52 (0.87–2.65) | 0.04 |
| Ulcerative Colitis | ||||||
| No. of cases | 31 | 41 | 57 | 49 | 51 | |
| Age-adjusted HR (95% CI) | 1.17 (0.73–1.86) | 1.00 | 0.79 (0.53–1.18) | 0.75 (0.49–1.14) | 0.88 (0.58–1.34) | 0.15 |
| Multivariate-adjusted HR (95% CI)§ | 1.24 (0.76–2.02) | 1.00 | 0.78 (0.52–1.17) | 0.75 (0.49–1.14) | 0.92 (0.60–1.40) | 0.17 |
*
Abbreviations: Hazard Ratio (HR), Confidence Interval (CI).
§
Models adjusted for age (months), smoking (never, past, current), oral contraceptive use (never, past/current), physical activity at baseline in quintile (MET-hours/week), BMI at age 18 (< 20, 20–24.9, 25–29.9, ≥ 30 kg/m2), menopausal hormone therapy (premenopause, never, current, past).