Table 2.
Concordant genes involved in fibrosis and inflammation by Ingenuity Pathway Analysis. Downregulated genes are shown in plain text. Upregulated genes are shown in italicized, bold text.
| Inflammation | Monoculture | Coculture |
|---|---|---|
| SAEC 6 h | SPHK1, IL33, SFRP1, CD9, MMP9, CFTR, INHBA, IL23A, EDNRA, EGF1, ATF3, CD47, FOXO3, HYAL1, PDE4D, RORA | SPHK1, CD38, MARCO, PNOC, CCL3, TIMD4, PRG2, ISG15, PTAFR, MMP14, INHBA, IL5, IL4, CCL24, ATF3, CD47, PDE4D, FOXO3, MSH2, RAG1, DEK, AOC3, HYAL1, PTX3, RORA, CAV1 |
| SAEC 24 h | CD9, ISG15, SFRP1, FOS, INHBA, IL1R1, IL5, EGR1, CFTR, ATF3, EDNRA,CD47, BLNK, PDE4D, HYAL1, FOXO3, RORA, IL16 | MARCO, ISG15, PTAFR, CCL3, SPHK1, MMP14, MMP9, INHBA, CD47, HYAL1, AOC3, PDE4D, DEK, CAV1 |
| HMVEC 6 h | XBP1 | SPHK1, RAG1, MSH2, DEK |
| HMVEC 24 h | CD69, XBP1, S11B, GRP, PRG2, BLNK, IL6, NR1D1, EFNB1, CXCR3 | SPHK1, RAG1, MSH2, DEK, CD47 |
| Fibrosis | Monoculture | Coculture |
| SAEC 6 h | INHBA, IL23A, EDNRA, EGR1, ATF3, CFTR, MMP9, BMP6, PLAC8, UBD, SNA1, HEY2, RORA | MMP14, INHBA, IL5, IL4, CCL24, ATF3, KCCN4, RGS16, KLK1, PTX3, RORA, CAV1, CBL, SMAD4, DAG1, PKD2 |
| SAEC 24 h | EGR1, CFTR, ATF3, EDNRA, IL5, IL1R1, INHBA, HEY2, CDK4, UBD, BMP6, HBEFG, SNAI1, IL16, RORA, MYLK3, P2RY1 | MMP14, MMP9, INHBA, KLK1, RGS16, KCCN4, CAV1 |
| HMVEC 6 h | CBL, CREB1, BMPR2, POSTN, SMAD4, PKD2 | |
| HMVEC 24 h | IL6, P2RY1, CXCR3 | CBL, CREB1, BMPR2, POSTN, SMAD4, PKD2, EGFR |