Table 3.
PUCAI Responsiveness Analysis
| Median change in PUCAI (IQR) | |
|---|---|
| a Improved (n = 69) | 35 (−10 to 75) |
| a Stable (n = 1760) | 0 (−5 to 5) |
| a Worsened (n = 45) | −40 (−80 to 0) |
| b Responsiveness statistic [MID/SDunchanged] | 1.18 |
| Correlation with change in PGA | 0.69 (p < 0.001) |
a
Groups categorized based on change in PGA and the corresponding statistics represent the median with IQR in parentheses
b
SDunchanged is the standard deviation of change in PUCAI for all the patients whose PGA is unchanged; Effect sizes are defined as: 0.2–0.5 = small effect, 0.5–0.8 = moderate effect, and >0.8 = large effect
PUCAI = Pediatric Ulcerative Colitis Activity Index; IQR = interquartile range; MID=minimal important difference; SD = standard deviation; PGA = Physician Global Assessment