Table 4.
Univariable and multivariable subhazard ratios (SHRs) and 95% confidence intervals (95% CI) for risk of post-transplant HCC recurrence with the Fine and Gray competing risks regression model.
| Univariable | Multivariable* | |||||
|---|---|---|---|---|---|---|
| Donor characteristics | SHR | 95% CI | p | SHR | 95% CI | p |
| Age >=60 (versus <60) | 1.66 | 1.28–2.14 | <0.001 | 1.70 | 1.31–2.20 | <0.001 |
| Ethnicity | ||||||
| White | 1 | |||||
| Black | 1.24 | 0.93–1.66 | 0.14 | |||
| Hispanic/Latino | 1.24 | 0.91–1.70 | 0.16 | |||
| Asian | 0.88 | 0.43–1.79 | 0.72 | |||
| Other/Multi-race | 1.64 | 0.62–4.36 | 0.32 | |||
| DCD | 1.14 | 0.71–1.80 | 0.54 | |||
| Partial or split liver (versus whole) | 1.61 | 0.88–2.91 | 0.12 | |||
| Cause of death | ||||||
| Anoxia | 1 | |||||
| Other | 1.26 | 0.64–2.48 | 0.50 | |||
| Stroke | 1.29 | 0.94–1.76 | 0.11 | |||
| Head trauma | 1.02 | 0.73–1.42 | 0.91 | |||
| Live donor (versus cadaveric) | 0.96 | 0.30–3.04 | 0.95 | |||
| Non-local organ sharing (versus local) | 1.45 | 1.13–1.85 | 0.003 | 1.42 | 1.09–1.84 | 0.009 |
| HBV core positive | 0.67 | 0.40–1.13 | 0.13 | |||
| CDC high risk donor | 1.08 | 0.75–1.55 | 0.69 | |||
| HCV positive | 0.77 | 0.40–1.49 | 0.43 | |||
| BMI | ||||||
| Underweight (BMI <18.5) | 1 | |||||
| Normal (BMI 18.5–24.9) | 1.28 | 0.63–2.62 | 0.49 | |||
| Overweight (BMI 25.0–29.9) | 1.25 | 0.61–2.56 | 0.54 | |||
| Obese (BMI >30) | 1.31 | 0.64–2.69 | 0.46 | |||
| Donor height (per cm increase) | 0.996 | 0.99–1.01 | 0.47 | |||
| CIT (per hour increase) | 0.997 | 0.95–1.04 | 0.89 | |||
*
Adjusted for wait time, tumor volume and size, ablative therapy, AFP>500 ng/mL and diagnosis as well as center clustering.