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. 2015 Jan 28;35(4):1659–1674. doi: 10.1523/JNEUROSCI.2925-14.2015

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Copyright © 2015 Spilsbury et al.

This article is freely available online through the J Neurosci Author Open Choice option.

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Figure 3. — TERT protein colocalizes with mitochondria under AD pathology. Representative series of sequential confocal images showing immunofluorescent labeling of TERT (green) and mitochondria (MTCO1, red) in CA2 hippocampal neurons from (A) a control and (B) a Braak Stage VI case (DAPI, blue). Images shown are from the middle section of Z-stacks containing a total of 20–24 planes. C, Maximum intensity projection images of TERT and mitochondria derived from Z-stack series covering the total section depth. D, Bar graphs represent Pearson's coefficients indicating the degree of colocalization between TERT and mitochondria in CA1, CA2, CA3, CA4, and DG regions of the hippocampus. Colocalization was increased in the CA1, CA2, and CA3 regions of AD (Braak VI) cases compared with the control group. Data are mean ± SEM from 3 cases per group. *p < 0.05 (one-way ANOVA with Tukey's post hoc test). **p < 0.01 (one-way ANOVA with Tukey's post hoc test). ns, Not significant. Scale bars, 50 μm; maximum intensity projection image, 20 μm.