Figure 8.

Pathological tau increases lipid peroxidation in TERT^−/− neurons. Neurons from wild-type and TERT^−/− mice were transduced with either truncated (A) or mutated (B) tau. Double-labeling with 4-HNE (red) and AT8 (green) was performed, and levels of lipid peroxidation were measured in the soma, apical dendrites, and basal dendrites. C, There were no differences in 4-HNE levels between wild-type and TERT^−/− neurons transduced with truncated tau. D, 4-HNE was increased in the soma of TERT^−/− neurons transduced with mutated tau. *p < 0.05 (one-way ANOVA with Tukey's post hoc test). Data are mean ± SEM from three independent experiments. Scale bars, 50 μm.