Figure 3.
Blocking M-current alters the frequency of spontaneous depolarizations. A, Current-clamp recording of AII responses to hyperpolarizing and depolarizing current injection. Note the lack of hyperpolarizing sag or of any spiking upon depolarization. B, Current-clamp recordings from AIIs show responses to injected current ramps in the absence and presence of the M-current antagonist linopirdine (LP). This protocol was used to measure the input resistance (RN) as a function of membrane potential. C, Summary data for effects of LP on resting potential of AIIs. D, Example recording of effects of LP on spontaneous depolarization in both AIIs and RGCs. Control trace same as that in Figure 2A. E, Summary data illustrate a reduction in average interwave interval. Dotted line represents distribution from Figure 2B.