Table 3.
Variables | PARP1 non-cleaved | PARP1 cleaved | ||||
---|---|---|---|---|---|---|
Negative n (%) | Positive n (%) | p value | Negative n (%) | Positive n (%) | p value | |
Menopausal status | ||||||
Pre | 182 (33.2) | 216 (41.7) | 0.004 | 65 (33.5) | 409 (38.5) | NS |
Post | 366 (66.8) | 302 (58.3) | 129 (66.5) | 653 (61.5) | ||
Age | ||||||
<50 | 163 (29.7) | 193 (36.9) | 0.012 | 61 (31.4) | 365 (34) | NS |
≥50 | 386 (70.3) | 330 (63.1) | 133 (68.6) | 710 (66) | ||
Tumour size | ||||||
≤2 cm | 279 (51.2) | 240 (46.1) | NS | 96 (50) | 523 (48.8) | NS |
>2 cm | 266 (48.8) | 281 (53.9) | 96 (50) | 548 (51.2) | ||
Tumour stage | ||||||
1 | 346 (62.9) | 310 (59.5) | NS | 129 (66.5) | 634 (59.2) | NS |
2 | 159 (28.9) | 164 (31.5) | 51 (26.3) | 342 (31.9) | ||
3 | 45 (8.2) | 47 (9.0) | 14 (7.2) | 95 (8.9) | ||
Tumour grade | ||||||
1 | 113 (20.7) | 69 (13.3) | 0.001 | 32 (16.7) | 180 (17.9) | NS |
2 | 180 (33) | 163 (31.3) | 61 (31.8) | 368 (34.5) | ||
3 | 253 (46.3) | 288 (55.4) | 99 (51.6) | 519 (48.6) | ||
Tubule formation | ||||||
1 | 35 (6.7) | 24 (4.7) | NS | 11 (5.9) | 62 (6) | NS |
2 | 181 (34.6) | 160 (31.6) | 57 (30.3) | 336 (32.6) | ||
3 | 307 (58.7) | 323 (63.7) | 120 (63.8) | 634 (61.4) | ||
Pleomorphism | ||||||
1 | 14 (2.7) | 10 (2) | <0.001 | 1 (0.5) | 29 (2.8) | NS |
2 | 233 (44.6) | 168 (33.1) | 76 (40.4) | 404 (39.2) | ||
3 | 275 (52.7) | 329 (64.9) | 111 (59) | 598 (58) | ||
Mitosis | ||||||
1 | 201 (38.4) | 145 (28.6) | 0.001 | 66 (35.1) | 373 (36.1) | NS |
2 | 103 (19.7) | 95 (18.7) | 30 (16) | 200 (19.4) | ||
3 | 219 (41.9) | 267 (52.7) | 92 (48.9) | 459 (44.5) | ||
Vascular invasion | ||||||
Negative | 185 (34) | 174 (33.5) | NS | 65 (34) | 355 (33.2) | NS |
Positive | 359 (66) | 346 (66.5) | 126 (66) | 714 (66.8) | ||
NPI groups | ||||||
Good | 190 (34.9) | 134 (25.7) | 0.005 | 63 (32.8) | 326 (30.4) | NS |
Moderate | 269 (49.4) | 295 (56.6) | 94 (49) | 566 (52.8) | ||
Poor | 86 (15.8) | 92 (17.7) | 35 (18.2) | 179 (16.7) |
Bold values indicate significance
NS not significant