Table 6.
Relationship between DNA repair biomarkers PARP1ceaved and non-cleaved with biomarkers in ER-positive and negative populations
| Variables | ER-positive | ER negative | |||||
|---|---|---|---|---|---|---|---|
| Negative n (%) | Positive n (%) | p value | Negative n (%) | Positive n (%) | p value | ||
| PARP1 non-cleaved | |||||||
| BRCA1 | Negative | 138 (44.5) | 105 (33.9) | 0.007 | 80 (72.1) | 73 (64) | NS |
| Positive | 172 (55.5) | 205 (66.1) | 31 (27.9) | 41 (36) | |||
| RAD51 | Negative | 197 (67) | 113 (39.9) | <0.001 | 77 (75.5) | 78 (69.6) | NS |
| Positive | 97 (33) | 170 (60.1) | 25 (24.5) | 34 (30.4) | |||
| CHK1 | Negative | 256 (77.3) | 216 (64.1) | <0.001 | 102 (85) | 106 (83.5) | NS |
| Positive | 75 (22.7) | 121 (35.9) | 18 (15) | 21 (16.5) | |||
| CHK2 | Negative | 135 (57.4) | 94 (39.8) | <0.001 | 66 (64.1) | 54 (53.5) | NS |
| Positive | 100 (42.6) | 142 (60.2) | 37 (35.9) | 47 (46.5) | |||
| PIASγ | Negative | 111 (32.5) | 48 (14.3) | <0.001 | 45 (36) | 26 (19.7) | 0.003 |
| Positive | 231 (67.5) | 288 (85.7) | 80 (64) | 106 (80.3) | |||
| DNA-PKcs | Negative | 58 (26) | 25 (10.5) | <0.001 | 23 (25.8) | 13 (13.3) | 0.029 |
| Positive | 165 (74) | 214 (89.5) | 66 (74.2) | 85 (86.7) | |||
| Ki67 | Negative | 126 (42.3) | 114 (36.4) | NS | 18 (16.7) | 8 (6.7) | 0.019 |
| Positive | 172 (57.7) | 199 (63.6) | 90 (83.3) | 111 (93.3) | |||
| ID4 | Negative | 323 (91.2) | 302 (90.1) | NS | 98 (77.2) | 106 (87.6) | 0.031 |
| Positive | 31 (8.8) | 33 (9.9) | 29 (22.8) | 15 (12.4) | |||
| P53 | Negative | 339 (85.2) | 277 (75.7) | 0.001 | 73 (53.3) | 51 (37.5) | 0.009 |
| Positive | 59 (14.8) | 89 (24.3) | 64 (46.7) | 85 (62.5) | |||
| PARP1 cleaved | |||||||
| RAD51 | Negative | 70 (81.4) | 264 (49.1) | <0.001 | 37 (90.2) | 126 (68.9) | 0.010 |
| Positive | 16 (18.6) | 274 (50.9) | 4 (9.8) | 57 (31.1) | |||
| CHK1 | Negative | 85 (82.5) | 428 (67.9) | 0.003 | 42 (89.4) | 175 (84.1) | NS |
| Positive | 18 (17.5) | 202 (32.1) | 5 (10.6) | 33 (15.9) | |||
| CHK2 | Negative | 52 (66.7) | 214 (45.2) | <0.001 | 27 (61.4) | 106 (58.9) | NS |
| Positive | 26 (33.3) | 259 (54.8) | 17 (38.6) | 75 (41.1) | |||
| PIASγ | Negative | 55 (50.9) | 113 (17) | <0.001 | 25 (48.1) | 51 (22.9) | <0.001 |
| Positive | 53 (49.1) | 552 (83) | 27 (51.9) | 172 (77.1) | |||
| DNA-PKcs | Negative | 26 (34.2) | 65 (13.6) | <0.001 | 18 (40.9) | 23 (14.3) | <0.001 |
| Positive | 50 (65.8) | 413 (86.4) | 26 (59.1) | 138 (85.7) | |||
| P53 | Negative | 112 (87.5) | 637 (79.8) | 0.040 | 25 (46.3) | 108 (43.4) | NS |
| Positive | 16 (12.5) | 161 (20.2) | 29 (53.7) | 141 (56.6) | |||
Bold values indicate significance