Table 1.

Randomized time-series experimental design for the Prevention Trial in the Cherokee Nation

A. Treatment Town: (n ≈ 250 youth)	O(M)ikt1(1)………O(M)ikt5(12)	XCONNECT 6(13)–19(54)	O(M)ikt6(13)………………..…19(54)
B. Treatment Town: (n ≈ 250 youth)	O(M)ikt1(1)………O(M)ikt5(12)	XCMCA 6(13)–19(54)	O(M)ikt6(13)…………..………19(54)
C. Treatment Towns (n = 2): (n ≈ 500 youth)	O(M)ikt1(1)………O(M)ikt5(12)	XCOMBINED 6(13)–19(54)	O(M)ikt6(13)……….....……….19(54)
D. Control Towns (n = 2): (n ≈ 500 youth)	O(M)ikt1(1)……………………………..……..…………………….….……..………….O(M)ikt19(54)
E. Control Towns (n = 6): (n ≈ 250 youth/town)	O(A)ikt1(1)………………………..……..…………………….….…………………..…..…O(A)ikt5(54)

i individual/person, k treatment condition, t time, O observation, O(M) monitoring system and archival sources, quarterly (monthly) observations/measures + archival sources, O(A) archival sources of yearly (monthly) observations/measures