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. 2014 Aug 5;15(1):84–94. doi: 10.1038/tpj.2014.34

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Metabolic profiling for tamoxifen (Tam) and five measured metabolites, N-desmethyltamoxifen (DM-Tam), N,N-didesmethyltamoxifen (DDM-Tam), (Z)-endoxifen, 4-hydroxytamoxifen [(Z)-4-OH-DDM-Tam] and norendoxifen [(Z)-4-OH-DDMT-Tam] in study cohorts from Singapore (Sing, N=164), Lebanon (Leb, N=78) and Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH, N=345). Metabolite concentrations are presented as boxplots with whiskers defined by the 5th and 95th percentiles and extreme values outside the whiskers. The two dashed lines for Tam delineate putative non-compliant (⩽40 nM) and poorly compliant (40–150 nM) patients as defined from Tam plasma concentrations. Patients with Tam concentrations <150 nM were excluded from further analyses.