Figure 5. Fitting the evolution models.
(A) Distribution of the clonal evolution pattern in the 60 non-Richter cases. Three of the 60 cases show replacement during tumor progression. (B) Scatter plot showing p-values of observing increased and decreased subclones in the 80 samples of the 60 multi-time point patients. Samples with evidence of clonal replacement are located in the right-up corner (highlighted by yellow circle). (C) Number of patients following linear vs branched evolution pattern according to SF3B1 mutational emergence and previous treatment (p-value 0.0016 by Fisher's exact test).