Table 2.
Clinical features at presentation of the CLL cohorts*
TEDG analysis | SA analysis | |||||
---|---|---|---|---|---|---|
N | Total | % | N | Total | % | |
IGHV homology >98% | 37 | 69 | 53.6 | 532 | 1380 | 38.6 |
del13q14 | 35 | 70 | 50.0 | 682 | 1403 | 48.6 |
+12 | 19 | 70 | 27.1 | 205 | 1403 | 14.6 |
del11q22-q23 | 8 | 70 | 11.4 | 136 | 1403 | 9.7 |
del17p13 | 20 | 70 | 28.6 | 114 | 1403 | 8.1 |
TP53 mutation | 22 | 70 | 31.4 | 114 | 1401 | 8.1 |
NOTCH1 mutation | 22 | 70 | 31.4 | 150 | 1403 | 10.7 |
SF3B1 mutation | 17 | 70 | 24.3 | 100 | 1403 | 7.1 |
MYD88 mutation | 6 | 70 | 8.6 | 52 | 1403 | 3.7 |
BIRC3 mutation | 10 | 70 | 14.3 | 41 | 1403 | 2.9 |
BIRC3 deletion | 6 | 70 | 8.6 | 79 | 1403 | 5.6 |
TEDG analysis, Tumor Evolutionary Directed Graphs analysis; SA analysis, Statistical Association analysis; IGHV, immunoglobulin heavy variable gene; FISH, fluorescence in situ hybridization.