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. 2015 Jan 28;5:8066. doi: 10.1038/srep08066

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(a) The RMSD values of the ligand with respect to the first snapshots of the simulations; (b) The distance between the side chain of Asn^5.50 and the nitrogen on the pyridine ring of CP-376395; (c) The distance between the backbone carbon atoms on Tyr^6.63 and His228^3.40 (CRF₁R) or between the backbone carbon atoms on Tyr^6.63 and Val228^3.40 (CRF₂R); (d) The distance between the side chain oxygen atoms on Tyr^6.63 and Gln^5.50; (e) Cross-section view of CRF₁R with the bottleneck formed; (f) Cross-section view of CRF₂R without the bottleneck. In (e) and (f), the antagonist binding pockets are colored in magenta.