Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Arthritis Rheumatol. 2014 Nov;66(11):3062–3072. doi: 10.1002/art.38780

Figure 2. Gene expression analysis of iPSC-derived cartilage following a 24 hr treatment with IL-1α.

Figure 2

Expression of inflammatory (Ccl2, Il6) and catabolic (Adamts4, -5, Mmp9, -13) genes were all increased in a dose dependent manner. These increases were significant at all doses of IL-1α. Expression of chondrogenic genes (Acan, Col2a1) were decreased following treatment with 1 ng/ml of IL-1α, but unchanged at lower doses. A 1-way ANOVA was used with Tukey’s post-hoc test. Data are presented as mean ± SEM, and groups not connected by the same letter are significantly different from each other.