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. Author manuscript; available in PMC: 2015 Jan 28.
Published in final edited form as: Drug Metab Lett. 2011 Apr;5(2):126–131. doi: 10.2174/187231211795305258

Table 1.

miRNAs predicted to target the UTRs of selected drug metabolizing CYPs.

CYP Gene Reference ID a 3′-UTR length (bp) Bioinformatic Programs b, c Total no. of unique miRNAs d Overlap e (%)
Micro Cosm miRanda Target Scan RNA22 PITA
1A1 NC_000015.8 (NM_000499) 946 14 2 85 264 14 332 47 (12.4)
1A2 NC_000015.8 (NM_000761) 1512 7 g 70 341 11 386 43 (10)
1B1 NC_000002.10 (NM_000104) 3119 1 49 215 345 40 499 151 (23.2)
2A6 NC_000019.8 (NM_000762) 257 g g 18 37 2 54 3 (5.3)
2B6 NC_000019.8 (NM_000767) 1569 5 g 125 347 27 416 88 (17.5)
2C8 NC_000010.9 (NM_000770) 355 35 g 31 65 2 114 19 (14.3)
2C9 NC_000010.9 (NM_000771) 362 46 g 34 77 9 129 37 (22.3)
2C19 L39102.1 f 57 g g g g 57 0
2D6 NC_000022.9 (NM_000106) 74 33 g g 4 4 40 1 (2.4)
2E1 NC_000010.9 (NM_000773) 152 24 g 10 5 g 35 4 (10.3)
3A4 NC_000007.12 (NM_017460) 1152 34 26 111 208 17 333 63 (15.9)
3A5 NC_000007.12 (NM_000777) 110 12 g 11 14 1 32 6 (15.8)
a

Reference sequence and the corresponding RefSeq Gene id from UCSC Genome browser in parenthesis.

b

PicTar predictions are not included in the table as the CYP genes do not appear to be a part of the program’s database.

c

Versions of the bioinformatic programs (retrieved on 07/12/2010): (A) MicroCosm Target uses miRNA Registry release 15.0, (B) for RNA22, we used miRNA Registry release 15.0, (C) MicroRNA.org and PITA use miRNA Registry release 11.0, and (D) TargetScan version 5.1 uses miRNA Registry release 10.1. Some of the predictions include multiple transcripts of the same gene.

d

Total number of unique miRNAs predicted by all the programs.

e

Total number of miRNAs predicted to target the genes by at least 2 programs.

f

No 3′-UTR sequence available in UCSC genome browser.

g

No results predicted for these CYPs by the corresponding bioinformatic program.