Table 2.
Changes in clinical measurements
| Baseline | 3 months | 6 months | 12 months | Repeated ANOVA a | ||
|---|---|---|---|---|---|---|
| F | P | |||||
| Average dose of QTP (mg/day) | - | 379.6 (231.7) | 418.5 (243.4) | 438.6 (261.7) | - | - |
| Weight (kg) | 56.9 (12.2) | 57.6 (12.4) | 57.0 (11.6) | 57.3 (10.7) | F(3,75) = 0.44 | 0.64 |
| HbA1C (%) | 4.97 (0.32) | 4.95 (0.37) | 4.98 (0.35) | 4.89 (0.32) | F(3,75) = 1.32 | 0.28 |
| PANSS | ||||||
| Positive symptoms | 18.1 (4.7) | 15.7 (4.8) | 16.4 (54.2) | 15.3 (4.1) | F(3,81) = 5.35 | <0.01 |
| Negative symptoms | 23.5 (5.2) | 21.5 (5.5) | 20.8 (6.2) | 19.6 (6.5) | F(3,81) = 11.40 | <0.01 |
| General pathological symptoms | 39.8 (10.2) | 36.8 (9.3) | 36.8 (10.5) | 34.7 (10.1) | F(3,81) = 7.83 | <0.01 |
| GAF | 42.4 (14.7) | 50.3 (12.7) | 51.7 (14.0) | 51.6 (15.6) | F(3,75) = 10.54 | <0.01 |
| AIS | 5.0 (3.1) | 4.9 (3.6) | 3.5 (2.9) | 3.7 (3.0) | F(3,75) = 3.35 | 0.04 |
| DIEPSS | 6.4 (4.9) | 3.9 (3.2) | 3.1 (2.8) | 3.0 (2.9) | F(3,81) = 13.74 | <0.01 |
| Prolactin (ng/ml) | 33.1 (26.2) | 17.8 (20.8) | 21.0 (27.0) | 19.9 (28.0) | F(3,69) = 4.04 | 0.02 |
| DAI-30 | −8.6 (3.2) | −5.0 (7.1) | −6.8 (5.2) | −6.3 (5.9) | F(3,69) = 2.78 | 0.07 |
| JSQLS | ||||||
| Psychosocial | 37.9 (13.5) | 37.2 (11.7) | 35.0 (11.6) | 35.3 (12.2) | F(3,66) = 1.42 | 0.25 |
| Motivation | 21.6 (2.9) | 20.2 (4.0) | 19.9 (2.8) | 19.7 (3.6) | F(3,66) = 2.23 | 0.11 |
| Symptoms and side effects | 16.7 (4.5) | 14.7 (4.3) | 14.4 (4.6) | 14.9 (5.4) | F(3,66) = 3.20 | <0.05 |
Values are expressed as the mean (SD) unless otherwise indicated.
a Post hoc analyses with Bonferroni correction: (pairs of comparison not specified here were all with P values of >0.05, BL baseline, 3 m 3 months, 6 m 6 months, 12 m 12 months) PANSS positive symptoms: BL vs 12 m (P = 0.02); PANSS negative symptoms: BL vs 3 m (P = 0.01), BL vs 6 m(P = 0.03), BL vs 12 m (P < 0.01), 3 m vs 12 m (P = 0.02); PANSS general pathological symptoms: BL vs 3 m (P = 0.02), BL vs 12 m (P < 0.01), 6 m vs 12 m (P = 0.03); GAF: BL vs 3 m (P < 0.01), BL vs 6 m (P < 0.01), BL vs 12 m (P < 0.01); Athens Insomnia Scale: BL vs 6 m (P = 0.03); DIEPSS: BL vs 3 m (P < 0.01), BL vs 6 m (P < 0.01), BL vs 12 m (P < 0.01); prolactin: BL vs 3 m (P < 0.01), BL vs 12 m (P < 0.01); JSQLS symptoms and side effects: BL vs 3 m (P = 0.03).
HbA1c hemoglobin A1c, PANSS Positive and Negative Symptoms Scale, GAF Global Assessment of Functioning, AIS Athens Insomnia Scale, DIEPSS Drug-Induced Extrapyramidal Signs Scale, DAI-30 Drug Attitude Inventory with 30 dichotomous items, JSQLS Schizophrenia Quality of Life Scale Japanese version.