Table 2.

Univariate analysis for overall recurrence-free survival among patients with T3-4a colorectal cancer

	Colorectal cancer (n = 277)		Rectal cancer (n = 104)		Colon cancer (n = 173)
Variables	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
miR-21 expression (low vs. high)	2.02 (1.18-3.45)	0.010	1.32 (0.62-2.85)	0.474	3.09 (1.41-6.76)	0.005
Age (<65 years vs. ≥65 years)	0.97 (0.57-1.66)	0.920	0.45 (0.20-1.02)	0.055	2.12 (0.95-4.77)	0.068
Tumor type (non-mucinous vs. mucinous)	1.18 (0.37-3.78)	0.783	3.03 (0.70-13.05)	0.138	0.67 (0.09-4.94)	0.693
Differentiation (well or moderately vs. poorly)	2.56 (1.09-6.00)	0.031	4.57 (1.33-15.67)	0.016	2.06 (0.60-7.00)	0.249
pT (T3 vs. T4a)	2.68 (1.51-4.76)	0.0005	3.97 (1.73-9.12)	0.001	2.30 (1.00-5.30)	0.044
Lymph node metastasis (absent vs. present)	3.69 (1.98-6.87)	0.00001	6.65 (2.30-19.22)	0.0004	2.24 (1.00-5.02)	0.045
CEA (<5 ng/dL vs. ≥5 ng/dL)	2.24 (1.26-3.99)	0.006	2.26 (1.02-5.05)	0.046	2.23 (0.97-5.15)	0.060
Adjuvant therapy (no vs. yes)	4.19 (0.58-30.35)	0.156	NA	NA	3.23 (0.44-23.98)	0.252

HR, hazard ratio; CI, confidence interval; NA, not available.