Table 4.
Characteristics of studies that evaluated the association between the high expression of miR-21 and recurrence-free survival or overall survival in colorectal cancer
| First author (reference) | Year | Origin | No. of cases | AJCC stage | Recurrence-free survival | Overall survival | Cut-off value | Statistic analysis | Detection method | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | ||||||||
| Schetter [13] | 2008 | USA | aCC 71 | I-IV | NA | NA | 2.7 | 1.3-5.5 | Third tertile | Multivariate | RT-PCR |
| China | aCC 103 | I-IV | NA | NA | 2.4 | 1.4-4.1 | Dichotomize | Multivariate | Microarray | ||
| Shibuya [18] | 2010 | Japan | CRC 156 | I-IV | 0.396 | 0.186-0.897 | 0.513 | 0.280-0.956 | Mean | Multivariate | RT-PCR |
| Nielsen [19] | 2011 | Denmark | CC 129 | II | 1.28 | 1.06-1.55 | 1.17 | 1.02-1.34 | Dichotomize | Multivariate | ISH |
| RC 67 | II | 0.85 | 0.73–1.01 | 0.97 | 0.83-1.13 | Dichotomize | Multivariate | ISH | |||
| Kjaer-Frifeldt [20] | 2012 | Denmark | CC 764 | II | 1.41 | 1.19-1.67 | 1.05 | 0.94-1.18 | Mean log | Multivariate | ISH |
| Zhang [29] | 2013 | China | CC 138 | II | 1.98 | 0.95-4.15 | NA | NA | Dichotomize | Univariate | RT-PCR |
| CC 137 | II | 1.88 | 0.95-3.75 | NA | NA | Dichotomize | Univariate | RT-PCR | |||
| CC 255 | II | 1.79 | 1.22-2.62 | NA | NA | Dichotomize | Univariate | RT-PCR | |||
| Bovell [30] | 2013 | USA | CRC 55 | IV | NA | NA | 3.25 | 1.37-7.72 | Mean | Multivariate | RT-PCR |
| Toiyama [31] | 2013 | Japan | CRC 166 | I-IV | NA | NA | 0.59 | 0.21-1.63 | 3.7 | Multivariate | RT-PCR |
| Chen [32] | 2013 | Taiwan | CRC 195 | I-IV | NA | NA | 1.655 | 0.992-2.762 | Mean | Univariate | RT-PCR |
| Hansen [33] | 2014 | Denmark | CC 554 | II | 1.348 | 1.032-1.760 | 1.075 | 0.889-1.301 | Dichotomize | Multivariate | RT-PCR |
| Oue [34] | 2014 | Japan | CC 156 | I-IV | NA | NA | 1.80 | 0.91-3.58 | Third tertile | Multivariate | RT-PCR |
| CC 87 | II-III | NA | NA | 3.13 | 1.20-8.17 | Third tertile | Multivariate | RT-PCR | |||
| Germany | CC 145 | II | NA | NA | 2.65 | 1.06-6.66 | Third tertile | Multivariate | RT-PCR | ||
| Present study | Korea | CC 173 | II-III | 3.09 | 1.41-6.76 | 0.425 | 0.142-1.271 | Dichotomize | Multivariate | ISH | |
| RC 104 | II-III | 1.32 | 0.62-2.85 | 2.046 | 0.557-7.513 | Dichotomize | Multivariate | ISH | |||
aOnly including patients with typical adenocarcinoma. AJCC, American Joint Committee on Cancer; CI, confidence interval; HR, hazard ratio; NA, not available; RT-PCR, reverse-transcription PCR; ISH, in situ hybridization; CC, colon cancer; RC, rectal cancer; CRC, colorectal cancer.