Table 10.
Uncharacterized Genes With Classifications That Match Biological Functions Deduced From Homology Information
| Symbol (GenBank accession number) | Gene name | Homology information | Classification | Classification matching assumed biological process (PMID reference) |
| LOC55977 (AA037007) | Hypothetical protein 24636 | Homo sapiens thromboxane A-2 receptor, 53%/55 aa | Protein metabolism and modification, lipid metabolism, developmental processes, blood coagulation | Developmental processes (10963722) blood coagulation (8777579) |
| FLJ10217 (W721889) | Oxysterol-binding protein-related protein 1 | H. sapiens oxysterol-binding protein, 36%/711 aa | Cell death, blood coagulation | Cell death (10617772) blood coagulation (10617772) |
| WW45 (H25014) | WW domain-containing gene | WW domain | Cell surface receptor-linked signal transduction, transcription | Transcription (11223034) |
| PIST (N68337) | PDZ/coiled-coil domain-binding partner for the rho-family GTPase TC10 | Mus musculus syntrophin, 43%/110 aa | Stress response, protein metabolism and modification, cell surface receptor-linked signal transduction, transcription | Stress response (10212242, 10797403) |
| ESTs (N33510) | ESTs, weakly similar to a chain A, human Cd69–trigonal form (SUB 82-199 (H. sapiens) | H. sapiens cd69, 52%/37 aa | Cell surface receptor-linked signal transduction, cell cycle, transcription | Cell surface receptor-linked signal transduction (11092246) |
| PTGFRN (AA045111) | Prostaglandin F2 receptor negative regulator | Ortholog of Ratius norvegicus prostaglandin F2 receptor negative regulator (http://www.ncbi.nlm.nih.gov/HomoloGene/homol.cgi) | Transcription, oncogenesis | Oncogenesis (11090944) |
| H-I(3)mbt-I (AA026761) | H-I(3)mbt-like protein | Drosophila melanogaster T13797 tumor suppressor protein, 46%/176 aa | Cell proliferation, lipid metabolism, transcription, oncogenesis | Cell proliferation, oncogenesis (10445843) |
| LOC57018 (AA016305) | Cyclin L ania-6a | H. sapiens cyclin K, 27%/363 aa | Cell proliferation, transcription, oncogenesis | Cell proliferation, transcription (9632813) |
| HMGE (AA037156) | GrpE-like protein cochaperone | Escherichia coli heat shock protein grpE, 32%/178 aa | Stress response, protein metabolism and modification | Stress response, protein metabolism and modification (10791710) |
| G2 (R16047) | G2 protein | H. sapiens G01449 probable mucin, 100%/1691 aa | Cell adhesion, cell cycle, DNA metabolism, protein targeting | Cell adhesion (1412714) |
| (H72723) | ESTs, highly similar to SMHU1B metallothionein 1B (H. sapiens) | H. sapiens SMHU1B metallothionein 1B, 98%/60 aa | Stress response, protein metabolism and modification, ion homeostasis | Stress response, ion homeostasis (10801901) |
This table shows the 11 out of 24 uncharacterized genes for which homology information could be found that allowed assumptions concerning functional classification of the gene, and one or more of the homology-based annotations matched the predicted (classified) biological process function.