TABLE 3.
ESAT-6- and CFP-10-specific T cell responsesa
| Parameter | Value for group |
P value | |
|---|---|---|---|
| Active TB (n = 26) | Latent TB (n = 33) | ||
| Median % of CD4 cells (25th–75th percentile) | |||
| CD154+ TNF-α+ | 0.085 (0.034–0.197) | 0.065 (0.022–0.152) | 0.182 |
| CD154+ TNF-α+ IFN-γ+ | 0.065 (0.019–0.155) | 0.038 (0.009–0.107) | 0.152 |
| CD154+ TNF-α+ GM-CSF+ | 0.041 (0.014–0.075) | 0.022 (0.005–0.049) | 0.086 |
| CD154+ TNF-α+ IL-2+ | 0.053 (0.018–0.106) | 0.045 (0.010–0.076) | 0.148 |
| CD154+ TNF-α+ IFN-γ+ IL-2+ | 0.042 (0.014–0.088) | 0.029 (0.006–0.060) | 0.119 |
| CD154+ TNF-α+ IFN-γ− IL-2− | 0.015 (0.010–0.030) | 0.010 (0.006–0.019) | 0.064 |
| CD154+ TNF-α+ CD27− | 0.053 (0.019–0.144) | 0.022 (0.008–0.069) | 0.035 |
| CD154+ TNF-α+ IFN-γ+ CD27− | 0.039 (0.012–0.120) | 0.016 (0.004–0.051) | 0.043 |
| CD154+ TNF-α+ GM-CSF+ CD27− | 0.029 (0.011–0.064) | 0.009 (0.003–0.022) | 0.003 |
| CD154+ TNF-α+ IL-2+ CD27− | 0.035 (0.009–0.067) | 0.012 (0.003–0.028) | 0.011 |
| CD4+ TNF-α+ CD154+ CXCR3+ | 0.007 (0.003–0.015) | 0.005 (0.002–0.014) | 0.526 |
| Median % of CD4+ TNF-α+ CD154+ cells (25th–75th percentile) | |||
| IFN-γ+ | 71.5 (57.5–77.5) | 65.5 (39.7–74.3) | 0.248 |
| GM-CSF+ | 39.0 (34.0–58.0) | 28.0 (24.0–41.0) | 0.026 |
| IL-2+ | 55.0 (45.5–67.0) | 54.0 (37.7–71.5) | 0.748 |
| IL-17A+ | 8.0 (4.0–15.0) | 12.0 (4.0–27.8) | 0.174 |
| IL-22+ | 9.0 (4.0–15.5) | 8.0 (4.5–14.5) | 0.982 |
| IL-2− IFN-γ− | 18.5 (14.0–27.3) | 24.0 (10.7–33.3) | 0.682 |
| IL-2+ IFN-γ+ | 46.5 (35.2–51.3) | 38.0 (23.2–54.3) | 0.163 |
| CXCR3+ | 10.0 (2.7–17.0) | 8.0 (4.0–14.0) | 0.977 |
| Median absolute no. of cells/ml (25th–75th percentile) | |||
| CD4+ TNF-α+ CD154+ | 541 (269–1,097) | 334 (155–1,008) | 0.216 |
| CD4+ TNF-α+ CD154+ IFN-γ+ IL-2+ | 262 (94–484) | 118 (35–468) | 0.172 |
| CD4+ TNF-α+ CD154+ IFN-γ− IL-2− | 106 (57–171) | 71 (41–115) | 0.082 |
| CD4+ TNF-α+ CD154+ CD27− | 335 (123–666) | 144 (39–446) | 0.032 |
| CD4+ TNF-α+ CD154+ IFN-γ+ CD27− | 249 (83–520) | 107 (19–354) | 0.038 |
| CD4+ TNF-α+ CD154+ GM-CSF+ CD27− | 197 (52–274) | 43 (19–137) | 0.012 |
| CD4+ TNF-α+ CD154+ IL-2+ CD27− | 182 (72–395) | 69 (20–182) | 0.017 |
| CD4+ TNF-α+ CD154+ CXCR3+ | 32 (17–90) | 28 (10–72) | 0.541 |
a
Results for Mann-Whitney U test comparisons between the active and latent groups are displayed.