. 2015 Jan 28;22(2):200–212. doi: 10.1128/CVI.00607-14

TABLE 4.

HBHA-specific T cell responses^a

Parameter	Value for group		P value
Parameter	Active TB (n = 17)	Latent TB (n = 26)	P value
Median % of CD4 cells (25th–75th percentile)
CD154⁺ TNF-α⁺ GM-CSF⁺	0.004 (0.002–0.015)	0.017 (0.013–0.045)	<0.001
CD154⁺ TNF-α⁺ IL-2⁺	0.013 (0.005–0.035)	0.042 (0.024–0.077)	<0.001
CD154⁺ TNF-α⁺ IFN-γ⁻ IL-2⁻	0.013 (0.002–0.021)	0.014 (0.007–0.026)	0.148
CD154⁺ TNF-α⁺ CD27⁻	0.014 (0.006–0.035)	0.029 (0.016–0.063)	0.101
CD154⁺ TNF-α⁺ IFN-γ⁺ CD27⁻	0.011 (0.003–0.023)	0.020 (0.012–0.042)	0.030
CD154⁺ TNF-α⁺ GM-CSF⁺ CD27⁻	0.003 (0.001–0.011)	0.010 (0.003–0.017)	0.041
CD154⁺ TNF-α⁺ IL-2⁺ CD27⁻	0.007 (0.003–0.017)	0.015 (0.007–0.033)	0.031
Median % of CD4⁺ TNF-α⁺ CD154⁺ cells (25th–75th percentile)
IFN-γ⁺	56.0 (37.0–64.0)	67.0 (62.0–76.0)	0.001
GM-CSF⁺	24.0 (11.2–32.5)	28.0 (22.0–39.0)	0.065
IL-2⁺	47.0 (32.0–59.0)	61.0 (45.0–73.0)	0.021
IL-17A⁺	5.0 (2.0–10.0)	2.0 (1.0–3.0)	0.024
IL-22⁺	2.5 (0.7–8.3)	1.5 (0.0–2.3)	0.132
IL-2⁻ IFN-γ⁻	29.0 (20.0–47.0)	21.0 (15.0–30.0)	0.044
IL-2⁺ IFN-γ⁺	30.0 (16.0–38.5)	50.0 (30.0–60.0)	0.001
CXCR3⁺	12.7 (2.5–18.0)	17.7 (8.0–26.0)	0.072
Median % of CD4⁺ TNF-α⁺ CD154⁺ CD27⁻ cells (25th–75th percentile)
Total	61.0 (47.0–68.0)	42.0 (36.0–53.0)	0.009
IFN-γ⁺	70.0 (49.0–76.5)	44.0 (33.0–55.0)	0.016
GM-CSF⁺	66.5 (48.5–78.8)	40.0 (29.0–51.0)	0.002
IL-2⁺	53.0 (44.0–66.5)	38.0 (30.0–44.0)	0.003
Median absolute no. of cells/ml (25th–75th percentile)
CD4⁺ TNF-α⁺ CD154⁺ IFN-γ⁻ IL-2⁻	71 (12–146)	82 (48–236)	0.130
CD4⁺ TNF-α⁺ CD154⁺ CD27⁻	101 (36–293)	190 (115–438)	0.109
CD4⁺ TNF-α⁺ CD154⁺ IFN-γ⁺ CD27⁻	58 (14–221)	135 (84–332)	0.055
CD4⁺ TNF-α⁺ CD154⁺ GM-CSF⁺ CD27⁻	15 (6–71)	59 (25–106)	0.025
CD4⁺ TNF-α⁺ CD154⁺ IL-2⁺ CD27⁻	45 (15–128)	110 (59–174)	0.043

Results for Mann-Whitney U test comparisons between the active and latent TB groups are displayed.