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. 2014 Dec 12;16:496. doi: 10.1186/s13058-014-0496-5

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© Guturi et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic representation of β-catenin/TCF4-dependent p68 gene regulation for enhanced tumourigenesis in cancer. Based on the previous reports and data from the current study, we propose this model. β-catenin can be stabilized and activated by aberrant Wnt signaling that upregulates p68 gene expression, which in turn is involved in increasing transcription factor 4 (TCF4) gene expression and forms a positive feedback loop that ultimately leads to enhanced expression of β-catenin target genes for enhanced tumourigenesis.