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. 2015 Jan 28;7(1):5. doi: 10.1186/s13073-014-0120-4

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© Ruklisa et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of pathogenicity prediction models for hypertrophic cardiomyopathy. Receiver operating characteristic curves for the full HCM model (full model, HCM) and a simpler gene model without domain-specific prediction (gene model, HCM) are shown alongside the LQTS classifier for comparison. As for BrS, the full HCM model was re-estimated in combination with the LQTS model with modest benefits at low false positive rates. BrS, Brugada syndrome; HCM, hypertrophic cardiomyopathy; LQTS, long QT syndrome.