Table 3.
Prevalence of TET1 , TET2 and TET3 mutations in hematological malignancies and solid tumors
| Cancer | TET1 mutation prevalence (%) | TET2 mutation prevalence (%) | TET3 mutation prevalence (%) |
|---|---|---|---|
| Myeloid malignancies | |||
| MDS | Not reported | 6-26 [78,79,165-169] | Not reported |
| MDS/MPN | |||
| CMML (adult) | Not reported | 20-58 [78,169-174] | Not reported |
| MPD | |||
| PV | Not reported | 6-16 [78,169,170] | Not reported |
| ET | Not reported | 4-5 [78,169,170] | Not reported |
| MF | Not reported | 2-17 [78,169,170] | Not reported |
| CML | Not reported | 2-4 [175,176] | Not reported |
| AML | |||
| De novo (adult) | Rare [141] | 12-27 [169,170,177-181] | Not reported |
| De novo (pediatric) | Not reported | 2-4 [182,183] | Not reported |
| Secondary AML | Not reported | 17-32 [80,85,184,185] | Not reported |
| Mastocytosis | Not reported | 20-29 [87,186] | Not reported |
| BPDCN | Not reported | 25-54 [187-189] | Not reported |
| Lymphoid malignancies | |||
| B-cell lymphoma | |||
| DLBCL | Not reported | 6-12 [39,81] | Not reported |
| MCL | Not reported | 0-4 [81,190] | Not reported |
| Follicular lymphoma | Not reported | 2 [81] | Not reported |
| CLL | Rare [142] | Not reported | Rare [142] |
| T cell lymphoma | |||
| AITL | Not reported | 33-83 [81,86,91,191,192] | Not reported |
| PTCL and PTCL, NOS | Not reported | 20-49 [81,86,91,191,192] | Rare [90] |
| T-ALL | Not reported | Not reported | Rare [143] |
| Solid tumors from | |||
| Endometrium | 9* | 7* | 4* |
| Breast | Rare [106] | Rare [115] | Rare* |
| Central nervous system | Rare [193] | Rare* | Rare* |
| Kidney | Rare* | Rare [113] | Rare* |
| Large intestine | 7 [105,137] | 4 [105,137] | 5 [105,137] |
| Liver | Rare [194] | Rare* | Rare [195] |
| Lung | 5 [106,114,138] | 2 [115,138,139] | Rare [138,139] |
| Ovary | Rare* | Rare* | Rare [112] |
| Pancreas | Rare [196,197] | Rare* | Rare* |
| Prostate | Rare [106,198] | Rare [198,199] | Rare [199] |
| Skin | Rare [109] | 1 [109] | Rare [116] |
| Stomach | 4 [200,201] | Not reported | Rare* |
| Urinary tract | 4 [140] | 4* | Rare* |
AITL, angioimmunoblastic T cell lymphoma; AML, acute myeloid leukemia; BPDCN, blastic plasmacytoid dendritic cell neoplasm; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; DLBCL, diffuse large B cell lymphoma; ET, essential thrombocytosis; FL, follicular lymphoma; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; MF, myelofribrosis; MDS/MPN, myelodysplastic syndrome/myeloproliferative neoplasm; MPD, myeloproliferative disorder; PV, polycythemia vera; PTCL, peripheral T cell lymphoma; PTCL,NOS, peripheral T cell lymphoma not otherwise specified; T-ALL, T-cell acute lymphoblastic leukemia; TET, Ten eleven translocation. *COSMIC database. Some mutations listed in this table have not been confirmed as somatic mutations.