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. 2015 Jan 24;23(1):6. doi: 10.1186/s40199-014-0086-1

Table 1.

Physical data of synthesized compounds (4–31)

Comp. no. R R' Mol. formula Yield (%) M.P. (°C) M.W. Elemental analysis calculated/found
C H N
4 H 3-OH C19H16N2O4S 57 289 368.41 61.94 4.38 7.60
61.90 4.34 7.55
5 3-OH H C19H16N2O4S 55 243 368.41 61.94 4.38 7.60
61.90 4.36 7.66
6 2-F H C19H14ClFN2O3S 52 186 370.40 56.37 3.49 6.92
56.33 3.44 6.88
6 2-F H C19H14ClFN2O3S 52 186 370.40 56.37 3.49 6.92
56.33 3.44 6.88
7 3-OH 3-OH C19H16N2O5S 58 129 348.41 59.37 4.20 7.29
59.32 4.16 7.24
8 H Cl C19H15ClN2O3S 55 183 386.85 58.99 3.91 7.24
58.55 3.89 7.26
9 2,4-CH3 4-CH3 C22H22N2O3S 62 284 394.49 66.98 5.62 7.10
66.95 5.56 7.05
10 2,5-CH3 2-OH C21H20N2O4S 64 302 396.46 63.62 5.08 7.07
63.58 5.11 7.10
11 2,4-CH3 2-OH C21H20N2O4S 58 189 396.46 63.62 5.08 7.07
63.58 5.11 7.11
12 3,5-CH3 2-OH C21H20N2O4S 56 293 396.46 63.62 5.08 7.07
63.59 5.06 7.02
13 2,4-OH 2-OH C19H16N2O6S 52 243 400.41 56.99 4.03 7.00
56.95 4.00 7.03
14 H 2-Cl, 4-CH3 C20H17ClN2O3S 58 109 400.88 59.92 4.27 6.99
59.88 4.24 6.95
15 H 4-Cl, 3-CH3 C20H17ClN2O3S 56 113 400.88 59.92 4.27 6.99
59.88 4.24 6.95
16 2-Cl 4-CH3 C20H17ClN2O3S 68 279 400.88 59.92 4.27 6.99
59.95 4.24 6.96
17 2,3,4-OH 4-CH3 C20H18N2O6S 44 253 414.43 57.96 4.38 6.76
59.95 4.42 6.72
18 3-OH 2-Cl,5-CH3 C20H17ClN2O4S 66 173 416.88 57.62 4.11 6.72
57.59 4.08 6.70
19 2-F 2-Cl,4-CH3 C20H16ClFN2O3S 60 175 418.87 57.35 3.85 6.69
57.30 3.81 6.66
20 3,5-CH3 2-Cl,4-CH3 C22H21ClN2O3S 55 308 428.93 61.60 4.93 6.53
61.56 4.88 6.49
21 2-Cl 4-NO2 C19H14ClN3O5S 58 282 431.85 52.84 3.27 9.73
52.86 3.21 9.69
22 2-Cl 2-NO2 C19H14ClN3O5S 66 174 431.85 52.84 3.27 9.73
52.86 3.21 9.69
23 4-Cl 2-NO2 C19H14ClN3O5S 52 240 431.85 52.84 3.27 9.73
52.86 3.22 9.70
24 2,3,4-OH 2-SH C19H16N2O6S2 53 119 432.47 52.77 3.73 6.48
52.74 3.68 6.44
25 2,4-OH 3-Cl,2-CH3 C20H17ClN2O5S 50 78 432.88 55.49 3.96 6.47
55.45 3.94 6.42
26 4-Cl 4-Cl,3-CH3 C20H16Cl2N2O3S 70 302 435.32 46.62 3.13 5.44
46.58 3.08 5.40
27 4-Cl 2-Cl,5-CH3 C20H16Cl2N2O3S 65 158 435.32 46.62 3.13 5.44
46.58 3.08 5.40
28 2-Br 2-OH C19H15BrN2O4S 52 113 447.30 51.02 3.38 6.26
51.10 3.40 6.30
29 2-Br 3-OH C19H15BrN2O4S 58 237 447.30 51.02 3.38 6.26
51.10 3.40 6.30
30 2-Br 2-NO2 C19H14BrN3O5S 62 297 476.66 47.91 2.96 8.82
47.88 2.94 8.85
31 3-Br 4-Cl,3-CH3 C20H16BrCl2N2O3S 67 309 479.77 50.07 3.36 5.84
50.11 3.31 5.80